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VMX Proceedings References: Stem Cell Applications in Dogs and Cats

by Rebecca Windsor DVM, DACVIM
  1. Black LL, Gaynor J, Gahring D, et al. Effect of adipose-derived mesenchymal stem and regenerative cells on lameness in dogs with chronic osteoarthritis of the coxofemoral joints: a randomized, double-blinded, multicenter, controlled trial. Vet Ther Res Appl Vet Med. 2007;8(4):272-284.
  2. Black LL, Gaynor J, Adams C, et al. Effect of intraarticular injection of autologous adipose-derived mesenchymal stem and regenerative cells on clinical signs of chronic osteoarthritis of the elbow joint in dogs. Vet Ther Res Appl Vet Med. 2008;9(3):192-200.
  3. Soltero-Rivera M, Goldschmidt S, Arzi B. Feline chronic gingivostomatitis: current concepts in clinical management. J Feline Med Surg. 2023;25(8):1098612X231186834. doi:10.1177/1098612X231186834
  4. Arzi B, Mills-Ko E, Verstraete FJM, et al. Therapeutic Efficacy of Fresh, Autologous Mesenchymal Stem Cells for Severe Refractory Gingivostomatitis in Cats. Stem Cells Transl Med. 2016;5(1):75-86. doi:10.5966/sctm.2015-0127
  5. Taechangam N, Walker NJ, Borjesson DL. Feline adipose-derived mesenchymal stem cells induce effector phenotype and enhance cytolytic function of CD8+ T cells. Stem Cell Res Ther. 2021;12(1):495. doi:10.1186/s13287-021-02558-5
  6. Teshima T, Yasumura Y, Suzuki R, Matsumoto H. Antiviral Effects of Adipose Tissue-Derived Mesenchymal Stem Cells Secretome against Feline Calicivirus and Feline Herpesvirus Type 1. Viruses. 2022;14(8):1687. doi:10.3390/v14081687
  7. Arzi B, Clark KC, Sundaram A, et al. Therapeutic Efficacy of Fresh, Allogeneic Mesenchymal Stem Cells for Severe Refractory Feline Chronic Gingivostomatitis. Stem Cells Transl Med. 2017;6(8):1710-1722. doi:10.1002/sctm.17-0035
  8. Arzi B, Peralta S, Fiani N, et al. A multicenter experience using adipose-derived mesenchymal stem cell therapy for cats with chronic, non-responsive gingivostomatitis. Stem Cell Res Ther. 2020;11(1):115. doi:10.1186/s13287-020-01623-9
  9. Febre M, Maddens S, Robert C, Rakic R, Plantier N, Saulnier N. Single infusion of allogeneic neonatal Mesenchymal stromal cells to manage refractory feline gingivostomatitis- A clinical pilot study. Cytotherapy. 2020;22(5):S102. doi:10.1016/j.jcyt.2020.03.182
  10. Soltero-Rivera M, Hart S, Blandino A, Vapniarsky N, Arzi B. Mesenchymal stromal cell therapy for feline chronic gingivostomatitis: Long term experience. Front Vet Sci. 2023;10:1171922. doi:10.3389/fvets.2023.1171922
  11. Febre M, Saulnier N, Roux P, et al. Placenta‐derived mesenchymal stromal cells as a treatment for refractory chronic gingivostomatitis in cats: eight cases (2018). J Small Anim Pract. 2023;64(4):296-305. doi:10.1111/jsap.13583
  12. Beerts C, Pauwelyn G, Depuydt E, et al. Homing of radiolabelled xenogeneic equine peripheral blood-derived MSCs towards a joint lesion in a dog. Front Vet Sci. 2022;9:1035175. doi:10.3389/fvets.2022.1035175
  13. Sajadi S, Khadembashiri MA, Raissi G, et al. The role of adipose-derived stem cells in knee osteoarthritis treatment: insights from a triple-blind clinical study. Stem Cell Res Ther. 2025;16(1):242. doi:10.1186/s13287-025-04233-5
  14. Sasaki A, Mizuno M, Mochizuki M, Sekiya I. Mesenchymal stem cells for cartilage regeneration in dogs. World J Stem Cells. 2019;11(5):254-269. doi:10.4252/wjsc.v11.i5.254
  15. Gruen ME, Messenger KM, Thomson AE, et al. Evaluation of serum cytokines in cats with and without degenerative joint disease and associated pain. Vet Immunol Immunopathol. 2017;183:49-59. doi:10.1016/j.vetimm.2016.12.007
  16. Gao X, Lee J, Malladi S, Melendez L, Lascelles BDX, Al-Murrani S. Feline degenerative joint disease: a genomic and proteomic approach. J Feline Med Surg. 2013;15(6):466-477. doi:10.1177/1098612X12470652
  17. Spitznagel MB, Gober MW, Patrick K. Caregiver burden in cat owners: a cross-sectional observational study. J Feline Med Surg. 2023;25(1):1098612X221145835. doi:10.1177/1098612X221145835
  18. Mitani K, Ito Y, Takene Y, Inaba T. Evaluation of the quality of life-enhancing effect of allogeneic feline adipose mesenchymal stem cells in cats with osteoarthritis: A pilot study. Res Vet Sci. 2025;182:105470. doi:10.1016/j.rvsc.2024.105470
  19. Enciso N, Amiel J, Pando J, Enciso J. Multidose intramuscular allogeneic adipose stem cells decrease the severity of canine atopic dermatitis: A pilot study. Vet World. 2019;12(11):1747-1754. doi:10.14202/vetworld.2019.1747-1754
  20. Webb TL, Webb CB. Stem cell therapy in cats with chronic enteropathy: a proof-of-concept study. J Feline Med Surg. 2015;17(10):901-908. doi:10.1177/1098612X14561105
  21. Webb TL, Webb CB. Comparing adipose-derived mesenchymal stem cells with prednisolone for the treatment of feline inflammatory bowel disease. J Feline Med Surg. 2022;24(8):e244-e250. doi:10.1177/1098612X221104053
  22. Cristóbal JI, Duque FJ, Usón-Casaús JM, Ruiz P, Nieto EL, Pérez-Merino EM. Effects of Allogeneic Mesenchymal Stem Cell Transplantation in Dogs with Inflammatory Bowel Disease Treated with and without Corticosteroids. Anim Open Access J MDPI. 2021;11(7):2061. doi:10.3390/ani11072061
  23. Cristóbal JI, Duque FJ, Usón-Casaús J, Barrera R, López E, Pérez-Merino EM. Complete Blood Count-Derived Inflammatory Markers Changes in Dogs with Chronic Inflammatory Enteropathy Treated with Adipose-Derived Mesenchymal Stem Cells. Animals. 2022;12(20):2798. doi:10.3390/ani12202798
  24. Reinero CR, Chang CH, Webb T, et al. Evaluation Of Mesenchymal Stem Cells For Experimental Feline Asthma; Results Of A Pilot Study. In: B37. NEW INSIGHTS INTO ASTHMA AND COPD TREATMENT. American Thoracic Society; 2012:A2852-A2852. doi:10.1164/ajrccm-conference.2012.185.1_MeetingAbstracts.A2852
  25. Trzil JE, Masseau I, Webb TL, et al. Intravenous adipose-derived mesenchymal stem cell therapy for the treatment of feline asthma: a pilot study. J Feline Med Surg. 2016;18(12):981-990. doi:10.1177/1098612X15604351
  26. Trzil JE, Masseau I, Webb TL, et al. Long-term evaluation of mesenchymal stem cell therapy in a feline model of chronic allergic asthma. Clin Exp Allergy J Br Soc Allergy Clin Immunol. 2014;44(12):1546-1557. doi:10.1111/cea.12411
  27. Zeira O, Asiag N, Aralla M, et al. Adult autologous mesenchymal stem cells for the treatment of suspected non-infectious inflammatory diseases of the canine central nervous system: safety, feasibility and preliminary clinical findings. J Neuroinflammation. 2015;12(1):181. doi:10.1186/s12974-015-0402-9
  28. Windsor RC, Stewart S, Cassano JM, et al. Intravenous allogeneic mesenchymal stromal cell therapy in 13 Pugs with presumptive early necrotizing meningoencephalitis. J Am Vet Med Assoc. Published online August 1, 2025:1-10. doi:10.2460/javma.25.05.0354

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