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Western Veterinary Conference Proceedings References

by Rebecca Windsor DVM, DACVIM
  1. Williams ZJ, Pezzanite LM, Chow L, Rockow M, Dow SW. Evaluation of stem-cell therapies in companion animal disease models: a concise review (2015-2023). Stem Cells. 2024;42(8):677-705. doi:10.1093/stmcls/sxae034
  2. Baranovskii DS, Klabukov ID, Arguchinskaya NV, et al. Adverse events, side effects and complications in mesenchymal stromal cell-based therapies. Stem Cell Investig. 2022;9:7-7. doi:10.21037/sci-2022-025
  3. Thompson M, Mei SHJ, Wolfe D, et al. Cell therapy with intravascular administration of mesenchymal stromal cells continues to appear safe: An updated systematic review and meta-analysis. EClinicalMedicine. 2020;19:100249. doi:10.1016/j.eclinm.2019.100249
  4. Soltero-Rivera M, Hart S, Blandino A, Vapniarsky N, Arzi B. Mesenchymal stromal cell therapy for feline chronic gingivostomatitis: Long term experience. Front Vet Sci. 2023;10:1171922. doi:10.3389/fvets.2023.1171922
  5. Rivas IL, Soltero-Rivera M, Vapniarsky N, Arzi B. Stromal cell therapy in cats with feline chronic gingivostomatitis: current perspectives and future direction. J Feline Med Surg. 2023;25(8):1098612X231185395. doi:10.1177/1098612X231185395
  6. Taechangam N, Iyer SS, Walker NJ, Arzi B, Borjesson DL. Mechanisms utilized by feline adipose-derived mesenchymal stem cells to inhibit T lymphocyte proliferation. Stem Cell Res Ther. 2019;10(1):188. doi:10.1186/s13287-019-1300-3
  7. Park SG, An JH, Li Q, et al. Feline adipose tissue-derived mesenchymal stem cells pretreated with IFN-γ enhance immunomodulatory effects through the PGE2 pathway. J Vet Sci. 2021;22(2):e16. doi:10.4142/jvs.2021.22.e16
  8. Williams V, Schneider JL, Parrish RS, et al. EXPRESS: Clinical field study evaluating the safety and efficacy of allogeneic uterine-derived mesenchymal stem cells for refractory feline chronic gingivostomatitis (FCGS). J Feline Med Surg. Published online September 25, 2025:1098612X251385852. doi:10.1177/1098612X251385852
  9. Wright A, Snyder L, Knights K, et al. A Protocol for the Isolation, Culture, and Cryopreservation of Umbilical Cord-Derived Canine Mesenchymal Stromal Cells: Role of Cell Attachment in Long-Term Maintenance. Stem Cells Dev. 2020;29(11):695-713. doi:10.1089/scd.2019.0145
  10. Johnston SA. Osteoarthritis. Vet Clin North Am Small Anim Pract. 1997;27(4):699-723. doi:10.1016/S0195-5616(97)50076-3
  11. Lascelles BDX, Henry Iii JB, Brown J, et al. Cross-Sectional Study of the Prevalence of Radiographic Degenerative Joint Disease in Domesticated Cats: Degenerative Joint Disease in Domestic Cats. Vet Surg. 2010;39(5):535-544. doi:10.1111/j.1532-950X.2010.00708.x
  12. Gruen ME, Messenger KM, Thomson AE, et al. Evaluation of serum cytokines in cats with and without degenerative joint disease and associated pain. Vet Immunol Immunopathol. 2017;183:49-59. doi:10.1016/j.vetimm.2016.12.007
  13. Gao X, Lee J, Malladi S, Melendez L, Lascelles BDX, Al-Murrani S. Feline degenerative joint disease: a genomic and proteomic approach. J Feline Med Surg. 2013;15(6):466-477. doi:10.1177/1098612X12470652
  14. Spitznagel MB, Gober MW, Patrick K. Caregiver burden in cat owners: a cross-sectional observational study. J Feline Med Surg. 2023;25(1):1098612X221145835. doi:10.1177/1098612X221145835
  15. Hillier TN, Watt MM, Grimes JA, Berg AN, Heinz JA, Dickerson VM. Dogs receiving cyclooxygenase-2–sparing nonsteroidal anti-inflammatory drugs and/or nonphysiologic steroids are at risk of severe gastrointestinal ulceration. J Am Vet Med Assoc. 2025;263(3):1-8. doi:10.2460/javma.24.06.0430
  16. Santoro D. Therapies in Canine Atopic Dermatitis. Vet Clin North Am Small Anim Pract. 2019;49(1):9-26. doi:10.1016/j.cvsm.2018.08.002
  17. Cosgrove SB, Wren JA, Cleaver DM, et al. Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. Vet Dermatol. 2013;24(5):479. doi:10.1111/vde.12047
  18. Moyaert H, Van Brussel L, Borowski S, et al. A blinded, randomized clinical trial evaluating the efficacy and safety of lokivetmab compared to ciclosporin in client‐owned dogs with atopic dermatitis. Vet Dermatol. 2017;28(6):593. doi:10.1111/vde.12478
  19. O’Neill DG, Church DB, McGreevy PD, Thomson PC, Brodbelt DC. Prevalence of disorders recorded in cats attending primary-care veterinary practices in England. Vet J. 2014;202(2):286-291. doi:10.1016/j.tvjl.2014.08.004
  20. Marino CL, Lascelles BDX, Vaden SL, Gruen ME, Marks SL. Prevalence and classification of chronic kidney disease in cats randomly selected from four age groups and in cats recruited for degenerative joint disease studies. J Feline Med Surg. 2014;16(6):465-472. doi:10.1177/1098612X13511446
  21. Chen F, Chen N, Xia C, et al. Mesenchymal Stem Cell Therapy in Kidney Diseases: Potential and Challenges. Cell Transplant. 2023;32:09636897231164251. doi:10.1177/09636897231164251
  22. Javard R, Grimes C, Bau‐Gaudreault L, Dunn M. Acute‐Phase Proteins and Iron Status in Cats with Chronic Kidney Disease. J Vet Intern Med. 2017;31(2):457-464. doi:10.1111/jvim.14661
  23. Uva A, Cavalera MA, Gusatoaia O, et al. Inflammatory Status and Chronic Kidney Disease in Cats: Old and New Inflammatory Markers—A Pilot Prospective Study. Animals. 2023;13(23):3674. doi:10.3390/ani13233674
  24. Quimby JM, Webb TL, Habenicht LM, Dow SW. Safety and efficacy of intravenous infusion of allogeneic cryopreserved mesenchymal stem cells for treatment of chronic kidney disease in cats: results of three sequential pilot studies. Stem Cell Res Ther. 2013;4(2):48. doi:10.1186/scrt198
  25. Quimby JM, Webb TL, Gibbons DS, Dow SW. Evaluation of intrarenal mesenchymal stem cell injection for treatment of chronic kidney disease in cats: A pilot study. J Feline Med Surg. 2011;13(6):418-426. doi:10.1016/j.jfms.2011.01.005
  26. Quimby JM, Webb TL, Randall E, Marolf A, Valdes-Martinez A, Dow SW. Assessment of intravenous adipose-derived allogeneic mesenchymal stem cells for the treatment of feline chronic kidney disease: a randomized, placebo-controlled clinical trial in eight cats. J Feline Med Surg. 2016;18(2):165-171. doi:10.1177/1098612X15576980
  27. Thomson AL, Berent AC, Weisse C, Langston CE. Intra‐arterial renal infusion of autologous mesenchymal stem cells for treatment of chronic kidney disease in cats: Phase I clinical trial. J Vet Intern Med. 2019;33(3):1353-1361. doi:10.1111/jvim.15486
  28. Webb TL, Webb CB. Stem cell therapy in cats with chronic enteropathy: a proof-of-concept study. J Feline Med Surg. 2015;17(10):901-908. doi:10.1177/1098612X14561105
  29. Cristóbal JI, Duque FJ, Usón-Casaús J, Martínez MS, Míguez MP, Pérez-Merino EM. Oxidative stress in dogs with chronic inflammatory enteropathy treated with allogeneic mesenchymal stem cells. Vet Res Commun. 2024;48(2):901-910. doi:10.1007/s11259-023-10265-0
  30. Cristóbal JI, Duque FJ, Usón-Casaús JM, Ruiz P, Nieto EL, Pérez-Merino EM. Effects of Allogeneic Mesenchymal Stem Cell Transplantation in Dogs with Inflammatory Bowel Disease Treated with and without Corticosteroids. Anim Open Access J MDPI. 2021;11(7):2061. doi:10.3390/ani11072061
  31. Cristóbal JI, Duque FJ, Usón-Casaús J, Barrera R, López E, Pérez-Merino EM. Complete Blood Count-Derived Inflammatory Markers Changes in Dogs with Chronic Inflammatory Enteropathy Treated with Adipose-Derived Mesenchymal Stem Cells. Animals. 2022;12(20):2798. doi:10.3390/ani12202798
  32. Pérez-Merino EM, Usón-Casaús JM, Zaragoza-Bayle C, et al. Safety and efficacy of allogeneic adipose tissue-derived mesenchymal stem cells for treatment of dogs with inflammatory bowel disease: Clinical and laboratory outcomes. Vet J. 2015;206(3):385-390. doi:10.1016/j.tvjl.2015.08.003
  33. Xie Q, Gong S, Cao J, et al. Mesenchymal stem cells: a novel therapeutic approach for feline inflammatory bowel disease. Stem Cell Res Ther. 2024;15(1). doi:10.1186/s13287-024-04038-y
  34. Reinero CR, Chang CH, Webb T, et al. Evaluation Of Mesenchymal Stem Cells For Experimental Feline Asthma; Results Of A Pilot Study. In: B37. NEW INSIGHTS INTO ASTHMA AND COPD TREATMENT. American Thoracic Society; 2012:A2852-A2852. doi:10.1164/ajrccm-conference.2012.185.1_MeetingAbstracts.A2852
  35. Trzil JE, Masseau I, Webb TL, et al. Intravenous adipose-derived mesenchymal stem cell therapy for the treatment of feline asthma: a pilot study. J Feline Med Surg. 2016;18(12):981-990. doi:10.1177/1098612X15604351
  36. Trzil JE, Masseau I, Webb TL, et al. Long-term evaluation of mesenchymal stem cell therapy in a feline model of chronic allergic asthma. Clin Exp Allergy J Br Soc Allergy Clin Immunol. 2014;44(12):1546-1557. doi:10.1111/cea.12411
  37. Zeira O, Asiag N, Aralla M, et al. Adult autologous mesenchymal stem cells for the treatment of suspected non-infectious inflammatory diseases of the canine central nervous system: safety, feasibility and preliminary clinical findings. J Neuroinflammation. 2015;12(1):181. doi:10.1186/s12974-015-0402-9
  38. Windsor RC, Stewart S, Cassano JM, et al. Intravenous allogeneic mesenchymal stromal cell therapy in 13 Pugs with presumptive early necrotizing meningoencephalitis. J Am Vet Med Assoc. Published online August 1, 2025:1-10. doi:10.2460/javma.25.05.0354

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